Why are we looking for new ways to renew our skin?
Skin aging is a multifactorial process – it results from the passage of time, oxidative stress, collagen loss, and also hormonal changes. With age, fibroblast activity declines, and levels of estrogen, androgens, and DHEA drop, as do levels of β-endorphins – molecules known as "happiness hormones." These endorphins are responsible not only for our well-being but also for skin regeneration and healthy metabolism .
It's no wonder cosmetology is searching for ways to restore skin's biochemical balance and activate its natural renewal mechanisms. The answer lies in phytoendorphins – modern plant ingredients that act like endorphins, improving the condition and appearance of the skin.
What are phytoendorphins?
Phytoendorphins are plant compounds that mimic the effects of endorphins – natural neurotransmitters present in our bodies. Endorphins are responsible for well-being, but also for skin health:
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accelerate regeneration,
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support wound healing,
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stimulate fibroblasts to produce collagen and elastin,
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improve microcirculation and cellular metabolism.
Phytoendorphins work in a very similar way – they activate opioid receptors in the skin, which translates into its renewal and younger appearance.
How do phytoendorphins work in cosmetics?
The inclusion of phytoendorphins in cosmetics provides a wide range of effects:
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Reduction of cellular stress – lowering cortisol levels in the skin.
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Improved elasticity and firmness – stimulation of fibroblasts.
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“Anti-stress” effect – the skin looks radiant, fresh and young.
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Strengthening the protective barrier – better resistance to external factors.
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Faster regeneration – acceleration of keratinocyte proliferation and epidermal renewal.
That is why phytoendorphins are called the neurocosmetic ingredients of the future – they act not only physiologically, but also emotionally on the skin.
Endorphins from ground pepper – the power of the Densorphin™ complex
The most important source of phytoendorphins in Orientana serum is Densorphin™ – a concentrated extract from the fruit of the pepper plant (Vitex agnus-castus). This 100% natural ingredient, approved by COSMOS, works in two ways:
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Stimulates the biosynthesis of β-endorphins – natural neurotransmitters responsible for the regeneration, elasticity and smoothness of the skin.
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Activates the production of DHEA (dehydroepiandrosterone) – a precursor of sex hormones (estrogens and androgens), which affects skin density.
Thanks to this, Densorphin™ is able to thicken mature skin, improve its elasticity and visibly reduce wrinkles – in both women and men.
Densorphin™ Research Results
The effectiveness of Densorphin™ has been confirmed in in vitro and clinical studies:
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Increased skin density after just 1 month of use.
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Visibly reduced wrinkles and improved skin elasticity.
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The “skin cushion” effect – restoration of volume lost during the aging process.
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Studies on women and men 50+ have shown that Densorphin™ effectively counteracts the loss of density and elasticity associated with menopause and andropause.
Red clover – support for mature skin
A key ingredient in Orientana serum is red clover extract , rich in phytoestrogens. These compounds mimic the effects of estrogen, which declines rapidly with age (especially during menopause).
Effects of red clover:
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improvement of skin density,
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increased hydration,
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reduction of symptoms of hormonal aging,
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protection against loss of elasticity.
Thanks to the synergy of phytoestrogens and phytoendorphins, the skin receives comprehensive support during menopause and after the age of 50 .
Lactic acid – gentle peeling and hydration
The second key ingredient in Orientana serum is lactic acid (AHA) . This is an extremely gentle acid that simultaneously exfoliates and moisturizes the skin.
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gently removes dead skin cells,
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smoothes the skin surface,
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improves the absorption of active ingredients,
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has a moisturizing effect thanks to the presence of the Natural Moisturizing Factor (NMF) .
Combined with phytoendorphins and red clover, lactic acid has a regenerating, brightening and smoothing effect on the skin .
Orientana Skin Renewal Activating Serum
Orientana was one of the first brands in Poland to use Densorphin™ in its innovative product: Skin Renewal Activating Serum .
Key ingredients of the serum:
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Phytoendorphins from ground pepper (Densorphin™) – activate regeneration and improve elasticity.
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Red clover – a source of phytoestrogens that support mature skin.
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Lactic acid – gentle exfoliation and hydration.
Effects confirmed by application tests:
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100% of respondents noticed smoother skin,
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100% confirmed the effect of renewal and regeneration,
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100% confirmed silky soft skin.
The serum is in line with the Orientana philosophy: natural ingredients + biotechnology = effectiveness and safety .
Who are cosmetics with phytoendorphins for?
Cosmetics with phytoendorphins are a solution for people who want to:
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reduce signs of fatigue and stress on the skin,
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improve its density and elasticity,
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strengthen the hydrolipid barrier,
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counteract hormonal aging (menopause, andropause),
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achieve the effect of fresh, radiant, regenerated skin.
Phytoendorphins in cosmetics are one of the newest and most promising anti-aging trends. They help skin regain its radiance, firmness, and self-regenerative capacity.
The Densorphin™ complex from ground pepper is particularly effective as it stimulates the synthesis of β-endorphins and DHEA, increasing skin density and elasticity and reducing wrinkles.
Orientana, a pioneer in combining nature and biotechnology, has created the Skin Renewal Activating Serum , which harnesses the power of phytoendorphins, phytoestrogens, and AHA acids. This cosmetic addresses the needs of skin in need of regeneration and supports its natural renewal at the cellular level.
👉 Check out Orientana Skin Renewal Activating Serum and discover how phytoendorphins can transform your skincare routine.
Phytoendorphins and Hormones: Frequently Asked Questions and Concerns
Are phytoendorphins hormones?
No. Phytoendorphins are plant compounds that act similarly to endorphins—natural neurotransmitters in our bodies. They are not hormones in the strict sense, but rather signaling substances that support cell communication in the skin and stimulate regenerative processes.
Does the use of phytoendorphins in cosmetics affect the hormonal balance of the entire body?
No. Phytoendorphins act only locally in the skin , activating receptors present in the epidermis and dermis. They do not enter the bloodstream, do not disrupt the hormonal system, and do not alter the levels of sex hormones in the body.
Can phytoendorphins disrupt the menstrual cycle or affect menopause?
No. Phytoendorphins used in cosmetics, such as the Orientana serum, act on the skin's surface . They can improve its density, elasticity, and radiance, especially in menopausal women, but they do not affect the menstrual cycle or internal processes.
What about complexes like Densorphin™ from ground pepper – don’t they increase hormone levels?
Densorphin™ doesn't act like a hormonal medication. Its role is to stimulate the local synthesis of β-endorphins and DHEA in the skin , molecules that are naturally produced there. This effect is limited to the application site and does not affect the entire body. In practice, this means improving skin density and elasticity, not interfering with hormonal balance.
Are phytoendorphins safe for men?
Yes. Clinical trials of Densorphin™ included both women and men aged 50+. Both groups observed improved skin density, wrinkle reduction, and increased elasticity. Phytoendorphins are not sex hormones, so they do not affect testosterone or estrogen.
Can phytoendorphins cause side effects like retinol?
No. Phytoendorphins are gentle and don't cause irritation or dryness. Unlike retinol, they don't cause exfoliation; in fact, they strengthen the hydrolipid barrier and improve skin comfort.
Can cosmetics with phytoendorphins be used together with hormone therapy (HRT)?
Yes, cosmetics with phytoendorphins are safe to use alongside HRT , as their effects are limited to the skin. They can even support the skin during this period, alleviating symptoms of hormonal aging, such as dryness and loss of firmness.
Are phytoendorphins in cosmetics regulated and tested?
Yes. Complexes like Densorphin™ are COSMOS-approved and have in vitro and in vivo studies. They have been proven to increase skin density, improve elasticity, and reduce wrinkles—without affecting systemic hormones.